Diagnostics and Gene Therapy for Human Genetic Disorders

Diagnostics and Gene therapy for Human Genetic disorders provides an integrative and comprehensive information blending the classical human genetics with the human genome. It provides a multidisciplinary overview of Mendelian inheritance and multifactorial inheritance, genetic variations, polymorphisms, chromosomal, multifactorial, and mitochondrial disorders. PCR, Electrophoresis, cytogenetics, prenatal and HPLC based techniques applied for diagnosing the genetic disorders were discussed with applications. Symptoms, etiology, diagnosis, treatment of 14 major and 5 minor genetic disorders were completely discussed. Methods employed for the preparation of kits for the diagnosis of the diseases were provided. Role of gene therapy on the amelioration of genetic disorders and the methodology employed has been discussed. The success of gene therapy in controlling various disorders such as immune system, neurodegenerative, cardiovascular, eye diseases and cancer has been provided along with type studies. Features: 1. Blend of classical human genetics with molecular and genome-based applications 2. Techniques applied for the diagnosis of the genetic disorders 3. Diagnostics of 19 genetic disorders including symptoms, etiology, diagnosis, and treatment. 4. Role of gene therapy in the amelioration of disorders 5. Type studies describing the role of diagnostics in conserving the human health. This book attempts to thread the information about the Human classical and modern genetics, genetic disorders, and gene therapy to all types of diseases under one roof. This work provides a comprehensive information that can be served as a reference book for scientific investigations and as a textbook for the graduate students.