Library Design, Search Methods, and Applications of Fragment-Based Drug Design

Content: Overview : fragment based drug design --
Designing and searching fragment libraries --
Validation of reaction vectors for de novo design --
Design and application of fragment libraries for protein crystallography --
Ligand-based virtual screening using Bayesian inference network --
A computational fragment approach by mining the protein data bank: library design and bioisosterism --
Computational screening : docking --
A fragment based docking engine : eHiTS --
Fragment-based high-throughput docking and library tailoring --
Leads from fragments : fragment growing and linking --
Fragment-based high-throughput docking and library tailoring --
Fragment-based drug discovery for diseases of the central nervous system.